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Medical research in the twentieth century mostly takes place in the lab; in the Renaissance, though, researchers went first and foremost to the library to see what the ancients had said.
Perhaps more than any other disease before or since, syphilis in early modern Europe provoked the kind of widespread moral panic that AIDS revived when it struck America in the 1980s.
Even more than this, however, the sick - like lepers - were often reviled because people believed that they had brought their torments upon themselves.
Was this an old disease, and, if so, which one? If it was new, what did that say about the state of medical knowledge? And in any case, how could physicians make sense of it?