Everyone knows what it's like to feel like the underdog. Everyone wants to be accepted. Ultimately, everybody wants to be loved.

Growing up in Rhode Island, my friends would have strung me up if I had been a Yankees fan.

I don't think you should just do what makes you happy. Do what makes you great.

You do not have to be fearless, just don't let fear stop you.

People are demanding so much of me. They really want to pigeonhole me.

I have expanded my mind and destroyed my liver but I didn't give up.

Cats do not abide by the laws of nature.

I'm not the biggest fan of comedies where nothing is real.

It doesn't really matter to me whether the 7-year-olds are big fans of my work. I'm happy just to be working at all. I do think it will be nice to have a movie that my son can watch.

Knowing that I'm not a model and I'm never going to be has relieved me of the pressure of looking good. If you don't establish yourself as McDreamy then you don't have to live up to it.

I eat stickers all the time dude!

I just want to do something that matters. Or be something that matters. I just want to matter.

Reason is neutral. It has no biases. It has no agendas. There are no personal interests at stake. Reason simply says, “Here is the data, be responsible with it.” As such, reason is impartial.

Design needs a new relationship with the world, one that is more focused on our planet's needs.

When I was a kid, I attended a small Catholic school in a south suburb of Chicago.

You never know when you're going to get an opportunity.

Whatever happens is going to happen, whether you're sitting by the phone anxious and worried about it or not.

The liberal groups spent months raising money so they could take down anyone President Bush nominated. But they have not been able to touch judge Roberts.

Money's the solution, curing all the ails of the nation. But what about the hearts of man?

Confronted with economic problems, politicians always blame the private sector first ... [even] blaming the problem on the solution.