Honestly, one-hour drama is the hardest format there is. I think it's harder than movies, and it's harder than half-hour comedy.

I think we're all fascinated and a little mystified by how the brain works. One of the most mysterious of the physical sciences is neurological science.

Sometimes time constraints bring out something cool.

[David Boreanaz]'s got a very, very cute little giggle.

Life is not just one dark moment after another.

In the same way that Shakespeare was writing very much for his time, he was also unearthing observations that would last for generations beyond him.

Anybody who believes and experiences their life and doesn't have shades of gray in it doesn't live where I live and is simply not in touch with the reality of the human condition.

Shakespeare is the Joss Whedon of his generation.

You learn a lot about a person when you work together.

The inherent corruption of man can often bring down the best system.

The American story is a story of great moments and dreadful moments.

A fool believes that math adds up, but also believes that they can master luck.

Power isn't free. Energy isn't free. It has to be earned.

The dark realization came to him that a difficult and miserable age had begun for him, and he couldn't imagine when it would end. [Puberty]

In every aspect of my life, I tend to look for the deeper side.

Let us never forget that government is ourselves and not an alien power over us.

None of Nature's landscapes are ugly so long as they are wild.

This letter really touched my heart. Sabrina says when she lost all her hair during chemo, she wore the cap I gave her.

Caring for an Alzheimer's patient is a situation that can utterly consume the lives and well-being of the people giving care, just as the disorder consumes its victims.

It sometimes is just the fear of being misunderstood.

Care is no cure, but rather corrosive, For things that are not to be remedied.