I always have my best thoughts on the toilet.

Growing up in Rhode Island, my friends would have strung me up if I had been a Yankees fan.

I don't think you should just do what makes you happy. Do what makes you great.

You do not have to be fearless, just don't let fear stop you.

People are demanding so much of me. They really want to pigeonhole me.

I have expanded my mind and destroyed my liver but I didn't give up.

Cats do not abide by the laws of nature.

I'm not the biggest fan of comedies where nothing is real.

It doesn't really matter to me whether the 7-year-olds are big fans of my work. I'm happy just to be working at all. I do think it will be nice to have a movie that my son can watch.

Knowing that I'm not a model and I'm never going to be has relieved me of the pressure of looking good. If you don't establish yourself as McDreamy then you don't have to live up to it.

I eat stickers all the time dude!

...most of the time, all you have is the moment, and the imperfect love of the people around you.

…on some occasions, women, like dreams, go by contraries.

We aren’t solid beings living on this planet

So, you know, I always say that I'm a Mexican, but if I had to be a citizen of anywhere else, I'd be a citizen of Manhattan. I feel very much a New Yorker.

On my darkest days, I wear my brightest colors.

I stay healthy through eating well, working out - simply living a healthy lifestyle.

I learned that a long walk and calm conversation are an incredible combination if you want to build a bridge.

I wanted to be a scientist. But I had no math skills.

There is no greater feeling than when a groom turns to see his bride and has tears in his eyes because she is so beautiful.

Now, it is my contention that the deneuroticization of humanity requires a rehumanization of psychotherapy.