I have expanded my mind and destroyed my liver but I didn't give up.

Growing up in Rhode Island, my friends would have strung me up if I had been a Yankees fan.

I don't think you should just do what makes you happy. Do what makes you great.

You do not have to be fearless, just don't let fear stop you.

People are demanding so much of me. They really want to pigeonhole me.

Cats do not abide by the laws of nature.

I'm not the biggest fan of comedies where nothing is real.

It doesn't really matter to me whether the 7-year-olds are big fans of my work. I'm happy just to be working at all. I do think it will be nice to have a movie that my son can watch.

Knowing that I'm not a model and I'm never going to be has relieved me of the pressure of looking good. If you don't establish yourself as McDreamy then you don't have to live up to it.

I eat stickers all the time dude!

Thinking of Plan B muddies up your chances of succeeding at Plan A.

Sometimes you need to let people do things for you, accept the gifts they have to offer, graciously accept it. It is a gift, Bridget, not a debt to be repaid.

They began their climb, already weary, and the sun tried to steal whatever strength they had left. It was another god, a forgotten god, who gave a daily reminder, and was forgotten again each night.

There is hardly a political question in the United States which does not sooner or later turn into a judicial one.

Mathematics, in its widest significance, is the development of all types of formal, necessary, deductive reasoning.

Oxford is the most dangerous place to which a young man can be sent.

I married the man of my dreams in 1998.

Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.

Ladies and gentlemen, you can't please everyone. Take my girlfriend - I think she's the most remarkable woman in the world. . . . That's me . . . But to my wife . . .

As soon as I get bored, I start missing the kids, so I dont let myself get bored. I just go surfing.

It is beautiful that there are three hundred religions in the world; more are needed. ... Each person should have his own religion - there should be as many religions as there are people!