My most romantic job: I was a manager at Baskin-Robbins.

I'm doing a very funny show in which we talk about issues. I speak at Aids charities and things. It's great to do something fun with our days and yet we're told we're doing something important.

I remember I had scenes with Melinda McGraw in "Ides Of March" that I didn't have in "Video Vigilante," but I can't quite picture that other character. But it was Vancouver, and that year was crazy

As a television actor, there's a power you're given to use your image to do something valuable. As a parent, these messages are particularly important to me.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

I always get a little uppity when I hear the phrase 'TV actor.' It's like saying you're a magazine reporter. I was in the theater for ten years before I ever had a TV audition.

I was raised on 'Get Smart' and 'All in the Family' and 'M.A.S.H.,' and certainly when 'Cheers' came along, that was a big one.

I think we all realize that anyone can - and has - gotten AIDS. So there's obviously still a lot to be done.

The thing you realize pretty quickly, though, is that being in front of an audience whose job it is to laugh is a big pressure if the writing is not hilarious.

As much as I loved [Al] Pacino and [Robert] De Niro and wanted to be a dramatic actor, I also grew up on sitcoms.

I've lived too long with pain. I won't know who I am without it.

There was only one way to the other side, and that was through the pain.

Unless you are silent, you will notknow your urgent heart, how it beatsbetween the thin skin of yes and no.

I like being on my own. I mean, I'm sure a Pack’s best for some dogs, but I've walked alone since I left my Pup Pack. I can look after myself.

It seems that most of us could benefit from a brush with a near-fatal disaster to help us recognise the important things that we are too defeated or embittered to recognise from day to day.

Cherish your friends and family as if your life depended on it. Because it does.

The foundation of beauty is the body.

If you're one of the more than 250 million Americans who already have health insurance, you will keep your health insurance. This law will only make it more secure and more affordable.

The terrible thing, the almost impossible thing, is the hand over your whole self--all your wishes and precautions--to Christ.

I'm not ready to be that guy who can meet with world leaders and all that. It's tremendous what Bono does. I don't know if I could do it, not the way he does. I don't think many people could.