My training makes me uneasy with a happy mystery.

Theories without data are like daydreams.

Though I learned little in my compromised state, I learned enough to make a decision: I was going to understand how mood could overwhelm. I was going to understand depression or die trying.

One reason we're not winning the fight against depression is that our available treatments leave so many in partial recovery limbo.

You know what you have to do, you just can't do it", Sara says wearily. "It's like you have bricks on your feet.

Just as a stressful life can make you depressed, continuing exposure to stressors maintains depression.

Depressed people don't end up lying in bed because they are undercommitted to goals. They end up lying in bed because they are overcommitted to goals that are failing.

I bet you have girls hanging all over you. Dozens would probably kill to be in my spot and here I am, allergic to your bread.” I looked up. “Why? Because of my near godlike perfection?

You can't break up what was never together. But my heart didn't get that memo.

They tell us variety is the spice of life - and yet diversity terrifies them.

I mean, I went to a Catholic boys' school for a year, but that was to play hockey. Religion class was quite contentious for me.

The most powerful idea that's entered the world in the last few thousand years - the idea of grace - is the reason I would like to be a Christian.

I don't get angry very often. I lose my temper rarely. And when I do, there's always a legitimate cause. Normally I have a great lightness of being. I take things in a very happy, amused way.

It was the first time that we had sort of articulated our major problem. She wanted to die and I wanted her to live and we were enemies who loved each other.

Pain is less subject than pleasure to careless expression.

The unhappy person is never present to themself because they always live in the past or the future.

There is, therefore, a more perfect intellectual life in the angels. In them the intellect does not proceed to self-knowledge from anything exterior, but knows itself through itself.