Nothing tends so much to the advancement of knowledge as the application of a new instrument.

Life is made up, not of great sacrifices or duties, but of little things, in which smiles and kindness, and small obligations given habitually, are what preserve the heart and secure comfort.

The most important of my discoveries have been suggested to me by failures.

I have learned more from my mistakes than from my successes.

Experimental science hardly ever affords us more than approximations to the truth; and whenever many agents are concerned we are in great danger of being mistaken.

We must reason in natural philosophy not from what we hope, or even expect, but from what we perceive.

Language is not only the vehicle of thought, it is a great and efficient instrument in thinking.

By science calmed, over the peaceful soul, Bright with eternal Wisdom's lucid ray, Peace, meek of eye, extends her soft control, And drives the puny Passions far away.

Consistency in opinion is the slow poison of intellectual life, the destroyer of its vividness and energy.

When two elements combine and form more than one compound, the masses of one element that react with a fixed mass of the other are in the ratio of small whole numbers.

Profound minds are the most likely to think lightly of the resources of human reason, and it is the superficial thinker who is generally strongest in every kind of unbelief.

He was attractive. I knew that. And I knew that attractive people always got away with things.

The saddest day in Pixar history was when some guy said 'get Larry the Cable Guy on the phone.

If there is such a thing as sin in this world, I think it must be shutting oneself up against hope.

I've never been someone to count lines, look at it that way.

There's the know. And there's the unknown. And what separates the two is the door, and that's what i wanta be. Ahh wanna be th' dooooooooorrr...

I would never censor something to please someone. I don't play games.

I can't deal with the press; I hate all those Beatles questions.

Tragedies are all right for a while: you are concerned, you are curious, you feel good. And then it gets repetitive, it doesn't advance, it grows dreadfully boring: it is so very boring, even for me.

The servants of God...whether provoked by word or work, by keeping themselves tranquil and peaceful, evince a perfect nobleness of soul.

The ripping and tearing of an unborn child from his mother's womb through the hands of another, and we say, "That's fine; you have a constitutional right to do that."