The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.

I'm doing a very funny show in which we talk about issues. I speak at Aids charities and things. It's great to do something fun with our days and yet we're told we're doing something important.

I remember I had scenes with Melinda McGraw in "Ides Of March" that I didn't have in "Video Vigilante," but I can't quite picture that other character. But it was Vancouver, and that year was crazy

As a television actor, there's a power you're given to use your image to do something valuable. As a parent, these messages are particularly important to me.

My most romantic job: I was a manager at Baskin-Robbins.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

I always get a little uppity when I hear the phrase 'TV actor.' It's like saying you're a magazine reporter. I was in the theater for ten years before I ever had a TV audition.

I was raised on 'Get Smart' and 'All in the Family' and 'M.A.S.H.,' and certainly when 'Cheers' came along, that was a big one.

I think we all realize that anyone can - and has - gotten AIDS. So there's obviously still a lot to be done.

The thing you realize pretty quickly, though, is that being in front of an audience whose job it is to laugh is a big pressure if the writing is not hilarious.

As much as I loved [Al] Pacino and [Robert] De Niro and wanted to be a dramatic actor, I also grew up on sitcoms.

People don't like it when you say real things.

You cannot save everyone. Some people are going to destroy themselves no matter how much you try to help them.

I actually feel like, for a lot of my career, I wasn't able to show my comedic range. I did a lot of dramas and dramedies. I was on 'E.R.' That's not generally thought of as a funny show.

I think of someone like Mariah Carey as a singer.

I’ve always hated being looked at.

Business is the most exciting game.

Never try and go on a solo mission on your own.

I don't like that [scaring] feeling and I watch the news every day because of it. It's going to be hard to fix all of these problems that seem absolutely unfixable to me.

Philosophy: a purple bullfinch in a lilac tree.

For oaths are straws, men's faiths are wafer-cakes, And hold-fast is the only dog.