[Townies] was a great springboard, obviously, because Jenna [Elfman] went from that to Dharma & Greg, and a few years later, Lauren [Graham] went to Gilmore Girls.

I'm doing a very funny show in which we talk about issues. I speak at Aids charities and things. It's great to do something fun with our days and yet we're told we're doing something important.

I remember I had scenes with Melinda McGraw in "Ides Of March" that I didn't have in "Video Vigilante," but I can't quite picture that other character. But it was Vancouver, and that year was crazy

As a television actor, there's a power you're given to use your image to do something valuable. As a parent, these messages are particularly important to me.

The Andromeda strain is a killer disease that they've got to prevent from spreading to being 100 percent contagious. It's another one where we're racing to save humanity.

My most romantic job: I was a manager at Baskin-Robbins.

When I read the script for Will & Grace in 1998, I knew I was the only guy for the part.

I always get a little uppity when I hear the phrase 'TV actor.' It's like saying you're a magazine reporter. I was in the theater for ten years before I ever had a TV audition.

I was raised on 'Get Smart' and 'All in the Family' and 'M.A.S.H.,' and certainly when 'Cheers' came along, that was a big one.

I think we all realize that anyone can - and has - gotten AIDS. So there's obviously still a lot to be done.

The thing you realize pretty quickly, though, is that being in front of an audience whose job it is to laugh is a big pressure if the writing is not hilarious.

Feelings of apathy as they relate to our relationships often stem from insufficiently paying attention to those around us.

If you want to live longer and to be strong, intelligent, loving, and kind--then don’t follow a tiger. Follow an elephant.

One who has imagination without learning has wings without feet.

For all evils there are two remedies - time and silence.

I think people that have fear that, 'Oh if I have a kid I won't be able to do this and I won't be able to do that.' It's kind of the opposite. It really gives you energy. It makes people better.

The essential difference between emotion and reason is that emotion leads to action while reason leads to conclusions.

When I get off a flight, I'm not trying to sit there and let them take pictures of me. I'm tired. I'm scratching my eyes. I just don't like taking pictures in general.

Remember the box fight: You start as a southpaw, you go back to fighting as a right-handed fighter.

As soon as you see something, you already start to intellectualize it. As soon as you intellectualize something, it is no longer what you saw.

If ever there was a holy war, it was that which saved our liberties and gave us independence.